Sickle cell disease classification using deep learning

This paper presents a transfer and deep learning based approach to the classification of Sickle Cell Disease (SCD). Five transfer learning models such as ResNet-50, AlexNet, MobileNet, VGG-16 and VGG-19, and a sequential convolutional neural network (CNN) have been implemented for SCD classification. ErythrocytesIDB dataset has been used for training and testing the models. In order to make up for the data insufficiency of the erythrocytesIDB dataset, advanced image augmentation techniques are employed to ensure the robustness of the dataset, enhance dataset diversity and improve the accuracy of the models. An ablation experiment using Random Forest and Support Vector Machine (SVM) classifiers along with various hyperparameter tweaking was carried out to determine the contribution of different model elements on their predicted accuracy. A rigorous statistical analysis was carried out for evaluation and to further evaluate the model's robustness, an adversarial attack test was conducted. The experimental results demonstrate compelling performance across all models. After performing the statistical tests, it was observed that MobileNet showed a significant improvement (p = 0.0229), while other models (ResNet-50, AlexNet, VGG-16, VGG-19) did not (p > 0.05). Notably, the ResNet-50 model achieves remarkable precision, recall, and F1-score values of 100 % for circular, elongated, and other cell shapes when experimented with a smaller dataset. The AlexNet model achieves a balanced precision (98 %) and recall (99 %) for circular and elongated shapes. Meanwhile, the other models showcase competitive performance. [Abstract copyright: © 2023 The Authors. Published by Elsevier Ltd.

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries